Wittig-horner approach for the synthesis of tamoxifen

TitleWittig-horner approach for the synthesis of tamoxifen
Publication TypeJournal Article
Year of Publication2005
AuthorsPandey, RK, Wakharkar, RD, Kumar, P
JournalSynthetic Communications
Volume35
Issue21
Pagination2795-2800
Date PublishedMAY
Type of ArticleArticle
ISSN0039-7911
Keywordsanticancer drug, phosphonate, stereoselectivity, Tamoxifen, Wittig-Horner reaction
Abstract

A stereoselective synthesis of Z -tamoxifen, a tetra-substituted alkene with antiestrogenic activity, is described. The Wittig-Horner reaction has been employed as the key step to establish the olefin stereochemistry.

DOI10.1080/00397910500290516
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.065

Divison category: 
Organic Chemistry