In vitro and ex vivo antitubercular activity of diarylheptanoids from the rhizomes of alpinia officinarum hance

TitleIn vitro and ex vivo antitubercular activity of diarylheptanoids from the rhizomes of alpinia officinarum hance
Publication TypeJournal Article
Year of Publication2016
AuthorsHonmore, VS, Rojatkar, SR, Nawale, LU, Arkile, MA, Khedkar, VM, Natu, AD, Sarkar, D
JournalNatural Product Research
Volume30
Issue24
Pagination2825-2830
Date PublishedMAR
Abstract

Phytochemical investigation of methanol extract of the rhizomes of Alpinia officinarum Hance afforded four known diarylheptanoids 1,7-diphenylhept-4-en-3-one (1), 5-hydroxy-1,7-diphenyl-3-heptanone (2), 5-hydroxy-7-(4 ''-hydroxy-3 ''-methoxyphenyl)-1-phenyl-3-heptanone (3), and 7-(4 ''-hydroxy-3 ''-methoxyphenyl)-1-phenyl heptan-3-one (4).The acetate derivative of (4), 7-(4 ''-actetate-3 ''-methoxy phenyl)-1-phenyl heptan-3-one (5), was prepared. These diarylheptanoids exhibited promising in vitro and ex vivo antitubercular activity for the first time against dormant Mycobacterium tuberculosis H37Ra with the IC50 values between 0.3447.69 and 0.1322.91 mu M, respectively. All compounds showed comparable activity against Mycobacterium bovis BCG (dormant phage) and did not show any activity against two gram + ve and two gram -ve bacterial strains. These compounds were also weakly cytotoxic up to 300 mu M against three human cancer cell lines THP-1, Panc-1 and A549.

DOI10.1080/14786419.2016.1149702
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.057

Divison category: 
Biochemical Sciences