Unimolecular antiparallel G-quadruplex folding topology of 2'-5'-isoTBA sequences remains unaltered by loop composition

TitleUnimolecular antiparallel G-quadruplex folding topology of 2'-5'-isoTBA sequences remains unaltered by loop composition
Publication TypeJournal Article
Year of Publication2015
AuthorsAher, MN
Secondary AuthorsErande, ND
Tertiary AuthorsFernandes, M
Subsidiary AuthorsKumar, VA
JournalOrganic & Biomolecular Chemistry
Volume13
Issue48
Pagination11696-11703
Date PublishedOCT
Type of ArticleJournal Article
Abstract

A 2'-5'-linked isoTBA 15 mer sequence with (232) loop composition formed stable antiparallel quadruplex structures similar to the SELEX derived 15 mer TBA sequence with (232) loop composition. A parallel versus antiparallel topology of 3'-5'-G-quadruplexes is largely dictated by the loop length, and it is known that the truncated loops favour parallel quadruplexes. In contrast to TBA, systematic reduction of the loop length in isoTBA from (232) to (222), (131) or even (111) did not alter the antiparallel topology of the resulting 14 mer, 13 mer and 11 mer G-rich modified isoTBA-like sequences. 

DOI10.1039/c5ob01923k
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.559

Divison category: 
Organic Chemistry