Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

TitleTris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles
Publication TypeJournal Article
Year of Publication2015
AuthorsPandit, KS, Chavan, PV, Desai, UV, Kulkarni, MA, Wadgaonkar, PP
JournalNew Journal of Chemistry
Volume39
Issue6
Pagination4452-4463
Date PublishedMAR
ISSN1144-0546
Abstract

simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles using a commercially available, inexpensive, non-toxic, and biodegradable tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. Ambient reaction conditions, wide scope, avoidance of conventional isolation as well as purification techniques and the reusability of the catalyst for five consecutive runs have improved the practical utility of this multicomponent reaction protocol manifold.

DOI10.1039/c4nj02346c
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.277

Divison category: 
Polymer Science & Engineering