Synthetic turn mimetics and hairpin nucleators: quo vadimus?

TitleSynthetic turn mimetics and hairpin nucleators: quo vadimus?
Publication TypeJournal Article
Year of Publication2014
AuthorsNair, RV, Baravkar, SB, Ingole, TS, Sanjayan, GJ
JournalChemical Communications
Volume50
Issue90
Pagination13874-13884
Date PublishedOCT
ISSN1359-7345
Abstract

Structural mimicry of peptides has witnessed perceptible progress in the last three decades. Reverse turn and beta-hairpin units are the smallest secondary structural motifs that are some of the most scrutinized functional cores of peptides and proteins. The practice of mimicking, without altering the function of the bioactive core, ranges from conformational locking of the basic skeleton to total replacement of structural architecture using synthetic analogues. Development of heterogeneous backbones - using unnatural residues in place of natural ones - has broadened further opportunities for efficient structural rigidification. This feature article endeavours to trail the path of progress achieved hitherto and envisage the possibilities that lie ahead in the development of synthetic turn mimetics and hairpin nucleators.

DOI10.1039/c4cc03114h
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

7.00

Divison category: 
Biochemical Sciences
Organic Chemistry