Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

TitleSynthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives
Publication TypeJournal Article
Year of Publication2017
AuthorsAbhale, YK, Shinde, A, Deshmukh, KK, Nawale, L, Sarkar, D, Mhaske, PC
JournalMedicinal Chemistry Research
Volume26
Start Page2557-2567
Issue10
Date PublishedJUN
ISSN1054-2523
KeywordsAntimicrobial activity, Antitubercular activit, Cytotoxicity, Thiazole, Thiosemicarbazide
Abstract

The increase in antibiotic resistance due to multiple factors has warranted the need for the search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent. © 2017, Springer Science+Business Media, LLC.

DOI10.1007/s00044-017-1955-1
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.607

Divison category: 
Biochemical Sciences