Synthesis, antioxidant, anti-inflammatory, and antimicrobial screening of newer thiophene-fused arylpyrazolyl 1,3,4-oxadiazoles

TitleSynthesis, antioxidant, anti-inflammatory, and antimicrobial screening of newer thiophene-fused arylpyrazolyl 1,3,4-oxadiazoles
Publication TypeJournal Article
Year of Publication2015
AuthorsMahajan, PS, Nikam, M, Chate, A, Nimbalkar, U, Patil, V, Bobade, A, Chaudhari, A, Deolankar, D, Javale, B, Gill, CH
JournalPhosphorus Sulfur and Silicon and the Related Elements
Volume190
Issue11
Pagination1803-1813
Date PublishedNOV
ISSN1042-6507
Keywords1, 3, 4-Oxadiazole, Anti-inflammatory, Antimicrobial, Antioxidant, EC50, Thiophene-fused pyrazole
Abstract

A series of newer 1,3,4-oxadiazole derivatives 3a-h, 5a-h containing a thiophene fused with pyrazole moiety of pharmacological significance have been synthesized. The compounds were characterized by H-1 NMR, IR, and mass spectral techniques. The compounds were screened for their in vitro antioxidant, anti-inflammatory and antimicrobial activities. Among them, Compounds 3b (EC50-14.98) and 3f (EC50-12.21) showed significant antioxidant activity. Compound 3a (EC50-15.23) showed good anti-inflammatory activity. Compound 3d was found as the most active derivative against bacterial and fungal strains.

DOI10.1080/10426507.2015.1024784
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

0.723

Divison category: 
Chemical Engineering & Process Development