Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach

TitleSynthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach
Publication TypeJournal Article
Year of Publication2010
AuthorsKategaonkar, AH, Shinde, PV, Kategaonkar, AH, Pasale, SK, Shingate, BB, Shingare, MS
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue7
Pagination3142-3146
Date PublishedJUL
ISSN0223-5234
Keywords1, 2, 2-Chloro3-formyl quinoline, 3-Triazole, Antibacterial, antifungal, Click chemistry
Abstract

Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) reaction of 3-(azidomethyl)-2-chloro-quinoline derivatives (3a-h) with phenyl acetylene in the presence of Cu(I) catalyst has been achieved in very high yield. These molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains. (C) 2010 Elsevier Masson SAS. All rights reserved.

DOI10.1016/j.ejmech.2010.04.002
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.193

Divison category: 
Polymer Science & Engineering