Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids

TitleSwitching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids
Publication TypeJournal Article
Year of Publication2013
AuthorsRamesh, VVE, Vijayadas, KN, Dhokale, SA, Gonnade, RG, Rajamohanan, PR, Sanjayan, GJ
JournalOrganic & Biomolecular Chemistry
Volume11
Issue41
Pagination7072-7075
Date PublishedNOV
ISSN1477-0520
Abstract

This communication describes the folding propensity of a hetero-foldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1:2:1 (alpha: beta: alpha) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio of the amino acid residues.

DOI10.1039/c3ob41369a
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.487

Divison category: 
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry