Simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature

TitleSimple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature
Publication TypeJournal Article
Year of Publication2014
AuthorsDesai, UV, Kulkarni, MA, Pandit, KS, Kulkarni, AM, Wadgaonkar, PP
JournalGreen Chemistry Letters and Reviews
Volume7
Issue3
Pagination228-235
Date PublishedJUN
ISSN1751-8253
Keywords5-dicarbonitriles, diethylamine, green chemistry, multicomponent reactions, organocatalyst, pyridine-3
Abstract

A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for ``green synthesis.''

DOI10.1080/17518253.2014.925144
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.512

Divison category: 
Polymer Science & Engineering