Problem solving and environmentally benign approach toward diversity oriented synthesis of novel 2-amino-3-phenyl (or Alkyl) sulfonyl-4H-chromenes at ambient temperature

TitleProblem solving and environmentally benign approach toward diversity oriented synthesis of novel 2-amino-3-phenyl (or Alkyl) sulfonyl-4H-chromenes at ambient temperature
Publication TypeJournal Article
Year of Publication2016
AuthorsPandit, KS, Kupwade, RV, Chavan, PV, Desai, UV, Wadgaonkar, PP, Kodam, KM
JournalACS Sustainable Chemistry & Engineering
Volume4
Pagination3450-3464
Date PublishedJUN
ISSN2168-0485
Keywords2-Amino-3-methylsulfonyl-4H-chromenes, 2-Amino-3-phenylsulfonyl-4H-chromenes, diethylamine, green chemistry, Multicomponent synthesis, organocatalyst
Abstract

A problem solving, environmentally benign, and diversity oriented protocol has been described for multi component synthesis of medicinally privileged 2-amino-3-phenyl (or methyl) sulfonyl-4H-chromenes by one-pot, three component condensation among aldehydes, phenyl (or methyl) sulphonyl acetonitrile, and alpha-naphthol, 3-dimethylamino phenol, 4-hydroxy-N-methyl-quinoline-2-one as well as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst. The catalyst employed is commercially available, inexpensive, and nontoxic. Ambient reaction conditions, very high yields, wide scope, and avoidance of conventional isolation as well as chromatographic purification have improved the practical utility of this protocol manifold.

DOI10.1021/acssuschemeng.6b00484
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

5.267

Divison category: 
Polymer Science & Engineering