Pd(II)-mediated alkynediol spiroketalization: first total synthesis of (-)-cephalosporolide E and (+)-cephalosporolide F

TitlePd(II)-mediated alkynediol spiroketalization: first total synthesis of (-)-cephalosporolide E and (+)-cephalosporolide F
Publication TypeJournal Article
Year of Publication2009
AuthorsRamana, CV, Suryawanshi, SB, Gonnade, RG
JournalJournal of Organic Chemistry
Volume74
Issue7
Pagination2842-2845
Date PublishedAPR
ISSN0022-3263
Abstract

Herein we describe a concise assembly of the central 1.6-dioxaspiro[4.4]nonane core of cephalosporolides E/F by employing a Pd-mediated alkynediol cycloisomerization and their total synthesis. On the basis of spectroscopic data and optical rotation values, the absolute configurations of cephalosporolides E/F were proposed.

DOI10.1021/jo802539z
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

4.002

Divison category: 
Organic Chemistry