Organocatalytic stereoselective synthesis of passifloricin A

TitleOrganocatalytic stereoselective synthesis of passifloricin A
Publication TypeJournal Article
Year of Publication2012
AuthorsKumar, P, Pandey, M, Gupta, P, Dhavale, DD
JournalOrganic & Biomolecular Chemistry
Volume10
Issue9
Pagination1820-1825
Date PublishedDEC
Type of ArticleArticle
ISSN1477-0520
Abstract

The enantioselective synthesis of passifloricin A has been achieved in high diastereomeric excess. The 1,3-polyol moiety was constructed by iterative proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes while the synthesis of lactone moiety was achieved by ring-closing metathesis (RCM).

DOI10.1039/c2ob06711k
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.568

Divison category: 
Organic Chemistry