Organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin

TitleOrganocatalytic route to the synthesis of lactone moiety of compactin and mevinolin
Publication TypeJournal Article
Year of Publication2010
AuthorsKumar, P, Pandey, M, Gupta, P, Dhavale, DD
JournalTetrahedron Letters
Volume51
Issue44
Pagination5838-5839
Date PublishedNOV
ISSN0040-4039
KeywordsAminoxylation, Compactin, Lactone, organocatalysis, Proline
Abstract

An efficient synthesis of lactone moiety of compactin has been achieved. The stereogenic centers were generated by means of iterative proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes. (C) 2010 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2010.08.093
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.618

Divison category: 
Organic Chemistry