One-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles

TitleOne-step synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines and their use in the synthesis of highly functionalized 2,3,5,6,7-and 2,3,4,5,7-substituted indoles
Publication TypeJournal Article
Year of Publication2011
AuthorsSawargave, SP, Kudale, AS, Deore, JV, Bhosale, DS, Divse, JM, Chavan, SP, Borate, HB
JournalTetrahedron Letters
Volume52
Issue42
Pagination5491-5493
Date PublishedOCT
ISSN0040-4039
Keywordsaldehydes, Dicyanoanilines, indoles, Malononitrile
Abstract

A three-component, one-step method for the synthesis of 4-alkyl-3-aryl-2,6-dicyanoanilines involving reaction of alkyl aldehyde, malononitrile and aryl aldehyde in presence of morpholine is reported. Highly functionalized 2,3,5,6,7- and 2,3,4,5,7-substituted indoles were prepared from these dicyanoanilines by reaction with ethyl bromoacetate. These substituted dicyanoanilines and indoles have a potential to be converted into various other compounds taking advantage of various functional groups present in these molecules. (C) 2011 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2011.08.064
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.683

Divison category: 
Organic Chemistry