New butenolide cinnamate and other biological active chemical constituents from Polygonum glabrum

TitleNew butenolide cinnamate and other biological active chemical constituents from Polygonum glabrum
Publication TypeJournal Article
Year of Publication2015
AuthorsSaid, MS, Chinchansure, AA, Nawale, L, Durge, A, Wadhwani, A, Kulkarni, SS, Sarkar, D, Joshi, SP
JournalNatural Product Research
Volume29
Issue22
Pagination2080-2086
Date PublishedNOV
ISSN1478-6419
Keywordsanti-HIV-1, anti-mycobacterium, antiproliferative, phytochemicals, Polygonaceae, Polygonum glabrum
Abstract

Phytochemical investigation of the methanol extract of the aerial parts of Polygonum glabrum afforded one new natural product (-)-2-methoxy-2-butenolide-3-cinnamate (1) along with six known compounds, -hydroxyfriedalanol (2), 3-hydroxy-5-methoxystilbene (3), (-) pinocembrin (4), sitosterol-(6-O-palmitoyl)-3-O–d-glucopyranoside (5), (-) pinocembrin-5-methyl ether (6) and sitosterol-3-O–d-glucopyranoside (7). Compound 1 showed promising in vitro anti-HIV-1 activity against primary isolates HIV-1(UG070) (X4, subtype D) and HIV-1(VB59) (R5, subtype C) assayed using TZM-bl cell line with IC50 in the range of 15.68-22.43g/mL. The extract showed TI in the range of 19.19-27.37 with IC50 in the range of 10.90-15.55g/mL. Compounds 1, 3 and 4 exhibited in vitro anti-mycobacterium activity against Mycobacterium tuberculosis H37Ra with IC50 values of 1.43, 3.33 and 1.11g/mL in dormant phase and 2.27, 3.33 and 1.21g/mL in active phase, respectively. Compound 4 was found to be the most active antiproliferative with IC50 values of 1.88-11.00g/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines.

DOI10.1080/14786419.2015.1004674
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.057

Divison category: 
Biochemical Sciences
Organic Chemistry