N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides

TitleN-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides
Publication TypeJournal Article
Year of Publication2011
AuthorsPadmanaban, M, Biju, AT, Glorius, F
JournalOrganic Letters
Volume13
Issue1
Pagination98–101
Date PublishedNOV
Abstract

N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.

DOI10.1021/ol102626p
Funding Agency

Council of Scientific & Industrial Research (CSIR) - India

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

6.17

Divison category: 
Organic Chemistry