Multifaceted folding in a foldamer featuring highly cooperative folds

TitleMultifaceted folding in a foldamer featuring highly cooperative folds
Publication TypeJournal Article
Year of Publication2012
AuthorsRamesh, VVE, Priya, G, Kotmale, AS, Gonnade, RG, Rajamohanan, PR, Sanjayan, GJ
JournalChemical Communications
Volume48
Issue91
Pagination11205-11207
Date PublishedSEP
ISSN1359-7345
Abstract

Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.

DOI10.1039/c2cc35649j
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

6.378

Divison category: 
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry