Multifaceted folding in a foldamer featuring highly cooperative folds
|Title||Multifaceted folding in a foldamer featuring highly cooperative folds|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Ramesh, VVE, Priya, G, Kotmale, AS, Gonnade, RG, Rajamohanan, PR, Sanjayan, GJ|
Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.
|Type of Journal (Indian or Foreign)|| |
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