Interaction of polymers with amyloidogenic peptides

TitleInteraction of polymers with amyloidogenic peptides
Publication TypeJournal Article
Year of Publication2018
AuthorsAbraham, JNixon, Nardin, C
JournalPolymer International
Date PublishedJAN
Type of ArticleArticle
Keywordsamyloid, neurodegenerative diseases, Polymer, protein, Self-assembly

With this review, the aim was to gather recent representative publications which describe the interaction of polymers with amyloidogenic peptides/proteins. When functional, these take part in for instance bacterial adhesion and biofilm formation. However, several of the peptides/proteins have been identified in various diseases. One of the current approaches to discover a cure against these relies on therapeutics which either prevent or accelerate peptide/protein aggregation and/or clear readily formed aggregates. Owing to the common interest of scientists from all disciplines to identify a cure against the diseases of public health concern, there are overwhelming numbers of publications dealing with these two approaches. Since amyloid aggregation could be regarded as a nucleated polymerization, which is an established mechanism of polymer self-assembly, we recently tackled the issue of amyloid aggregation using the theories and methods established in polymer science. In this review, we hence focus on gathering relevant and recent publications which describe the role of polymers in modulating the aggregation of amyloidogenic peptides/proteins. (c) 2017 Society of Chemical Industry

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Polymer Science & Engineering