From insertion to multicomponent coupling: temperature dependent reactions of arynes with aliphatic alcohols
|Title||From insertion to multicomponent coupling: temperature dependent reactions of arynes with aliphatic alcohols|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Thangaraj, M, Bhojgude, SSuresh, Mane, MV, Biju, AT|
The temperature dependent selectivity switch in the reaction of arynes with aliphatic alcohols in THF has been reported. At -20 degrees C, arynes smoothly insert into the O-H bond of alcohols to form alkyl aryl ethers. Interestingly, at 60 degrees C, a highly selective multicomponent coupling occurs with the solvent THF acting as the nucleophilic trigger affording (4-(alkoxy)butoxy)arenes.
|Type of Journal (Indian or Foreign)|| |
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