Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation-Michael addition-cyclization sequence under catalyst- and solvent-free conditions

TitleHighly efficient regioselective synthesis of pyrroles via a tandem enamine formation-Michael addition-cyclization sequence under catalyst- and solvent-free conditions
Publication TypeJournal Article
Year of Publication2015
AuthorsVivekanand, T, Vinoth, P, Agieshkumar, B, Sampath, N, Sudalai, A, Menendez, C, Sridharan, V
JournalGreen Chemistry
Volume17
Issue6
Pagination3415-3423
Date PublishedAPR
ISSN1463-9262
Abstract

A convenient catalyst-free, three-component procedure was developed for the synthesis of tetrasubstituted pyrroles under solvent-free conditions and in green solvents glycerol, PEG-200 and water. A sequential enamine-formation, Michael addition and intramolecular cyclization of primary amines, 1,3-dicarbonyl compounds and isatin-derived Michael acceptors afforded 3-(1H-pyrrol-3-yl)indolin-2-ones in excellent yields. In this simple one-pot transformation the requirement of column chromatography purification of the products was completely avoided. Besides, the method is highly environmentally benign and atom-economical, and the only side product of this reaction was two molecules of water. A comparative study for the four developed conditions showed that the solvent-free conditions were superior regardless of the nature of the starting materials, and the green solvents were effective for alkyl and benzylamines affording higher yields compared to arylamines. The preliminary in vitro cytotoxic studies of a representative compound against Ehrlich's ascites carcinoma (EAC) tumor cells showed significant activity with a CTC50 value of 15.64 mu M.

DOI10.1039/c5gc00365b
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

8.506

Divison category: 
Chemical Engineering & Process Development