Highly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery

TitleHighly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery
Publication TypeJournal Article
Year of Publication2012
AuthorsPatil, KM, Naik, RJ, Rajpal,, Fernandes, M, Ganguli, M, Kumar, VA
JournalJournal of the American Chemical Society
Volume134
Issue17
Pagination7196-7199
Date PublishedMAY
ISSN0002-7863
Abstract

The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)(4) or (r-ahx-r-r-apr-r)(2) increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells.

DOI10.1021/ja210026m
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

10.677

Divison category: 
Organic Chemistry