Highly efficient one-pot multi-component synthesis of alpha-aminophosphonates and bis-alpha-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular eval

TitleHighly efficient one-pot multi-component synthesis of alpha-aminophosphonates and bis-alpha-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular eval
Publication TypeJournal Article
Year of Publication2014
AuthorsMulla, SAbdul Rash, Pathan, MY, Chavan, SS, Gample, SP, Sarkar, D
JournalRSC Advances
Volume4
Issue15
Pagination7666-7672
Date PublishedJAN
ISSN2046-2069
Abstract

A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of alpha-aminophosphonate derivatives (4a-x) in excellent yields. The alpha-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.

DOI10.1039/c3ra45853a
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.98

Divison category: 
Chemical Engineering & Process Development
Organic Chemistry