Heterogeneous foldamers from aliphatic-aromatic amino acid building blocks: current trends and future prospects

TitleHeterogeneous foldamers from aliphatic-aromatic amino acid building blocks: current trends and future prospects
Publication TypeJournal Article
Year of Publication2014
AuthorsNair, RV, Vijayadas, KN, Roy, A, Sanjayan, GJ
JournalEuropean Journal of Organic Chemistry
Volume46
Issue9
Pagination7763-7780
Date PublishedDEC
ISSN1434-193X
KeywordsAmino acids, Conformation analysis, Foldamers, hydrogen bonding, Peptides, Stacking interactions
Abstract

Chemists' constant pursuit of understanding of the underlying principles of nature's most intricate phenomenon such as protein folding has led to the development of the field of foldamers. The emergence of diverse classes of unnatural amino acid building blocks has unleashed countless opportunities to design, develop and explore the structural and functional aspects of synthetic peptides. One current trend in foldamer chemistry is the heterofoldamer approach, which involves systematic stoichiometric variation of various natural/unnatural amino acid residues, leading to conformational ordering with intriguing structural architectures. In this regard, the incorporation of aromatic amino acids provides efficient structural rigidification and tunability to the molecular scaffolds, which can exhibit a range of secondary structural features. Recent times have witnessed an upsurge of foldamers featuring aliphatic-aromatic residues with diverse structural propensities. This review is an effort to cover this rapidly developing field of foldamer science and also to envisage its future perspectives.

DOI10.1002/ejoc.201402877
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.13

Divison category: 
Organic Chemistry