Helically structured peptide architecture engineered using dimedone as a rigid organic scaffold
|Title||Helically structured peptide architecture engineered using dimedone as a rigid organic scaffold|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Nadimpally, KC, Madica, K, Kotmale, AS, Gonnade, RG, Sanjayan, GJ|
This communication reports the use of a rigid organic scaffold to attach two unsymmetrical peptide chains on a single carbon atom. The approach describes the step-by-step attachment of peptide chains to the rigid dimedone template (5,5-dimethyl-1,3-cyclohexanedione) - a molecular scaffold that directs orientation of the peptide helices in a well-defined arrangement via intra-molecular hydrogen bonding. The overall topology of the final molecules was studied using CD spectroscopy which suggested existence of helical architecture.
|Type of Journal (Indian or Foreign)|| |
|Impact Factor (IF)|| |