Helically structured peptide architecture engineered using dimedone as a rigid organic scaffold

TitleHelically structured peptide architecture engineered using dimedone as a rigid organic scaffold
Publication TypeJournal Article
Year of Publication2018
AuthorsNadimpally, KC, Madica, K, Kotmale, AS, Gonnade, RG, Sanjayan, GJ
JournalChemistrySelect
Volume3
Issue10
Pagination2776-2780
Date PublishedMAR
Abstract

This communication reports the use of a rigid organic scaffold to attach two unsymmetrical peptide chains on a single carbon atom. The approach describes the step-by-step attachment of peptide chains to the rigid dimedone template (5,5-dimethyl-1,3-cyclohexanedione) - a molecular scaffold that directs orientation of the peptide helices in a well-defined arrangement via intra-molecular hydrogen bonding. The overall topology of the final molecules was studied using CD spectroscopy which suggested existence of helical architecture.

DOI10.1002/slct.201702856
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.505

Divison category: 
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry