Functional isoDNA aptamers: modified thrombin binding aptamers with a 2'-5'-linked sugarphosphate backbone (isoTBA)

TitleFunctional isoDNA aptamers: modified thrombin binding aptamers with a 2'-5'-linked sugarphosphate backbone (isoTBA)
Publication TypeJournal Article
Year of Publication2014
AuthorsGunjal, AD, Fernandes, M, Erande, ND, Rajamohanan, PR, Kumar, VA
JournalChemical Communications
Volume50
Issue5
Pagination605-607
Date PublishedNOV
ISSN1359-7345
Abstract

The regioisomeric 3'-deoxy-2'-5'-linked thrombin binding DNA aptamers (isoTBAs) were chemically synthesized and their ability to form unimolecular anti-parallel G-quadruplexes in the presence of K+ ions was evaluated. These modified sequences retain the function of the native thrombin binding aptamer (TBA), exhibit better stability against exonuclease and are capable of slowing down the process of blood clotting.

DOI10.1039/c3cc47569g
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

7.00

Divison category: 
Organic Chemistry