Facile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation

TitleFacile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation
Publication TypeJournal Article
Year of Publication2016
AuthorsSubhedar, DD, Shaikh, MH, Khan, FAKalam, Sangshetti, JN, Khedkar, VM, Shingate, BB
JournalNew Journal of Chemistry
Volume40
Issue4
Pagination3047-3058
Date PublishedFEB
ISSN1144-0546
Abstract

The one-pot three-component syntheses of new N-sulfonamide-thiazolidin-4-one derivatives were carried out in excellent yield using [HDBU][HSO4] as an ionic liquid under solvent-free conditions. The newly synthesized compounds were screened against fungal strains and a number of compounds were seen to display excellent antifungal activity. In addition, the synthesized compounds were screened for their scavenging activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and showed very good antioxidant activity. Finally, theoretical predictions derived from molecular docking studies against the potential target sterol 14 alpha-demethylase (CYP51) helped establish a link between the observed biological activity and the binding affinity, thereby providing insights into the specific bonding and non-bonding interactions governing the activity.

DOI10.1039/c6nj00021e
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.277

Divison category: 
Biochemical Sciences