Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents

TitleFacile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents
Publication TypeJournal Article
Year of Publication2016
AuthorsSubhedar, DD, Shaikh, MH, Arkile, MA, Yeware, A, Sarkar, D, Shingate, BB
JournalBioorganic & Medicinal Chemistry Letters
Volume26
Issue7
Pagination1704-1708
Date PublishedAPR
ISSN0960-894X
KeywordsAntitubercular, Cytotoxicity, Green protocol, Multicomponent reaction
Abstract

We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116. (C) 2016 Elsevier Ltd. All rights reserved.

DOI10.1016/j.bmcl.2016.02.056
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.486

Divison category: 
Organic Chemistry