Facile regioselective decomposition of tosylhydrazones: an application towards the synthesis of alpha-lipoic acid

TitleFacile regioselective decomposition of tosylhydrazones: an application towards the synthesis of alpha-lipoic acid
Publication TypeJournal Article
Year of Publication2005
AuthorsChavan, SP, Kale, RR, Pasupathy, K
JournalSynlett
Issue7
Pagination1129-1132
Date PublishedMAY
Type of ArticleArticle
ISSN0936-5214
Keywordsalpha-lipoic acid, Olefins, Regioselectivity, tosylhydrazones
Abstract

A facile regioselective decomposition of tosylhydrazones using NaOH as a base in refluxing isopropyl alcohol is described. This finding has been Successfully applied towards the synthesis of (±)-α-lipoic acid (1).

DOI10.1055/s-2005-865217
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.323

Divison category: 
Organic Chemistry