Facile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking

TitleFacile and solvent-free domino synthesis of new quinolidinyl-2,4-thiazolidinones: antifungal activityand molecular docking
Publication TypeJournal Article
Year of Publication2018
AuthorsSubhedar, DD, Shaikh, MH, Tupe, SG, Deshpande, MV, Khedkar, VM, Jha, PC, Shingate, BB
JournalMini-Reviews in Medicinal Chemistry
Volume18
Issue7
Pagination622-630
Date PublishedJAN
Abstract

Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation-alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst.

Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity.

Conclusion: Again, the molecular docking study performed against the fungal sterol 14 alpha-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design.

DOI10.2174/1389557516666161226161152
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.661

Divison category: 
Biochemical Sciences