Efficient total synthesis of calothrixin B

TitleEfficient total synthesis of calothrixin B
Publication TypeJournal Article
Year of Publication2012
AuthorsBhosale, SM, Gawade, RL, Puranik, VG, Kusurkar, RS
JournalTetrahedron Letters
Volume53
Issue23
Pagination2894-2896
Date PublishedJUN
ISSN0040-4039
KeywordsCalothrixin B, CAN, DMF-methanol, Hydride donor
Abstract

An efficient synthesis of calothrixin B (2) is demonstrated starting from 9H-carbazol-4-ol, having two one-pot reaction sequences as key steps. As a novel observation, DMF-methanol was shown to be a hydride donor for reduction of aldehyde to alcohol. Unexpectedly, nucleophilic substitution of benzyloxy by methoxy group was observed. (C) 2012 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2012.03.131
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.397

Divison category: 
Physical and Materials Chemistry