Efficient synthesis of gamma-keto sulfones by NHC-catalyzed intermolecular stetter reaction

TitleEfficient synthesis of gamma-keto sulfones by NHC-catalyzed intermolecular stetter reaction
Publication TypeJournal Article
Year of Publication2012
AuthorsBhunia, A, Yetra, SReddy, Bhojgude, SSuresh, Biju, AT
JournalOrganic Letters
Volume14
Issue11
Pagination2830–2833
Date PublishedMAY
Abstract

The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon–carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.

DOI10.1021/ol301045x
Funding Agency

Council of Scientific & Industrial Research (CSIR) - India

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

6.142

Divison category: 
Organic Chemistry