Efficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework

TitleEfficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework
Publication TypeJournal Article
Year of Publication2017
AuthorsChavan, SS, Supekar, MV, Burate, PA, Rupanwar, BD, Shelke, AM, Suryavanshi, G
JournalOrganic & Biomolecular Chemistry
Volume15
Issue11
Pagination2385-2391
Date PublishedMAR
Abstract

A novel Sn(II)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to construct the azetidine core through sequential Knoevenagel condensation, hydration and the C-N cyclization reaction.

DOI10.1039/c7ob00294g
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.559

Divison category: 
Chemical Engineering & Process Development