Efficient one-pot synthesis of alpha-amino phosphonates catalyzed by bismuth nitrate pentahydrate

TitleEfficient one-pot synthesis of alpha-amino phosphonates catalyzed by bismuth nitrate pentahydrate
Publication TypeJournal Article
Year of Publication2007
AuthorsBhattacharya, AK, Kaur, T
JournalSynlett
Issue5
Pagination745-748
Date PublishedMAR
Type of ArticleArticle
ISSN0936-5214
Keywordsaldehydes, alkyl phosphite, alpha-amino phosphonates, amines, bismuth nitrate pentahydrate, synthetic methods
Abstract

A simple, efficient, and environmentally benign method has been developed for the synthesis of alpha-amino phosphonates through a one-pot reaction of aldehydes with amines and diethyl phosphite in the presence of bismuth nitrate pentahydrate as a catalyst. Some of the major advantages of this protocol are: good yields, the involvement of a less-expensive and non-toxic catalyst, mild and solvent-free reaction conditions and also tolerance towards other functional groups present in the substrates. Eighteen examples are described, highlighting the substrate scope of the reaction.

DOI10.1055/s-2007-970762
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.323

Divison category: 
Biochemical Sciences
Organic Chemistry