Desymmetrization approach to the enantiopure syn/anti-1,5-diols via hydrolytic kinetic resolution (hkr) of functionalized meso-bis-epoxides: further elaboration to syn/syn-1,3,5-triols and application to the formal synthesis of cryptocarya diacetate

TitleDesymmetrization approach to the enantiopure syn/anti-1,5-diols via hydrolytic kinetic resolution (hkr) of functionalized meso-bis-epoxides: further elaboration to syn/syn-1,3,5-triols and application to the formal synthesis of cryptocarya diacetate
Publication TypeJournal Article
Year of Publication2013
AuthorsKumar, P, Chowdhury, PSarathi, Pandey, M
JournalAdvanced Synthesis & Catalysis
Volume355
Issue9
Pagination1719-1723
Date PublishedJUN
ISSN1615-4150
Keywordsbis-epoxides, cryptocarya diacetate, desymmetrization, stereoselective reduction, synthetic methods
Abstract

A new approach has been developed for the synthesis of enantiopure syn/anti-1,5-diols by desymmetrization of functionalized meso-bis-epoxides using hydrolytic kinetic resolution (HKR). The usage of this protocol was demonstrated by converting syn-1,5-diols into syn/syn-1,3,5-triols and its subseqent application to the formal synthesis of cryptocarya diacetate.

DOI10.1002/adsc.201300098
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

5.542

Divison category: 
Organic Chemistry