Cu(OTf)(2) or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of alpha-aminonitriles

TitleCu(OTf)(2) or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of alpha-aminonitriles
Publication TypeJournal Article
Year of Publication2006
AuthorsParaskar, AS, Sudalai, A
JournalTetrahedron Letters
Volume47
Issue32
Pagination5759-5762
Date PublishedAUG
Type of ArticleArticle
ISSN0040-4039
Keywordsaldehydes, aminonitriles, multicomponent reactions, organocatalyst, Strecker reaction
Abstract

Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing alpha-aminonitriles in excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2006.06.008
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.347

Divison category: 
Chemical Engineering & Process Development