Cu(I)-promoted one-pot `SNAr-click reaction' of fluoronitrobenzenes

TitleCu(I)-promoted one-pot `SNAr-click reaction' of fluoronitrobenzenes
Publication TypeJournal Article
Year of Publication2009
AuthorsDurugkar, KA, Gonnade, RG, Ramana, CV
JournalTetrahedron
Volume65
Issue20
Pagination3974-3979
Date PublishedMAY
ISSN0040-4020
Abstract

A one-pot two-step sequence involving a nucleophilic aromatic substitution (SNAF) of activated fluorobenzenes with azide nucleophile and in situ Huisgen cycloaddition of the resulting aryl azides with alkynes has been developed for a rapid access to 1,4-substituted triazoles. Control experiments revealed that both the steps are catalyzed by Cu(I) and also the course of reaction as SNAr followed by [3+2]-cycloaddition. (C) 2009 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tet.2009.03.035
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.011

Divison category: 
Organic Chemistry