cRGD functionalized nanocarriers for targeted delivery of bioactives

TitlecRGD functionalized nanocarriers for targeted delivery of bioactives
Publication TypeJournal Article
Year of Publication2019
AuthorsGajbhiye, KRai, Gajbhiye, V, Siddiqui, IA, Gajbhiye, JM
JournalJournal of Drug Targeting
Date PublishedFEB
Type of ArticleArticle
Keywordsalpha(v)beta(3) integrin receptors, cancer, cRGD, nanocarriers, targeting

The integrins αvβ3 play a very imperative role in angiogenesis and are overexpressed in endothelial cells of the tumor. Recent years have witnessed huge exploration in the field of αvβ3 integrin-mediated bioactive targeting for treatment of cancer. In these studies, the cRGD peptide has been employed extensively owing to their binding capacity to the αvβ3 integrin. Principally, RGD-based approaches comprise of antagonist molecules of the RGD sequence, drug-RGD conjugates, and most importantly tethering of the nanocarrier surface with the RGD peptide as targeting ligand. Targeting tumor vasculature or cells via cRGD conjugated nanocarriers have emerged as a promising technique for delivering chemotherapeutic drugs and imaging agents for cancer theranostics. In this review, primary emphasis has been given on the application of cRGD-anchored nanocarriers for targeted delivery of drugs, imaging agents, etc. for tumor therapy.

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Divison category: 
Organic Chemistry