Copper-catalyzed synthesis of 2-unsubstituted, n-substituted benzimidazoles

TitleCopper-catalyzed synthesis of 2-unsubstituted, n-substituted benzimidazoles
Publication TypeJournal Article
Year of Publication2009
AuthorsHirano, K, Biju, AT, Glorius, F
JournalJournal of Organic Chemistry
Volume74
Issue24
Pagination9570–9572
Date PublishedNOV
Abstract

An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-tert-butylphenyl and tolerating various functional groups demonstrate the utility of this method.

DOI10.1021/jo902160y
Funding Agency

Council of Scientific & Industrial Research (CSIR) - India

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

4.002

Divison category: 
Organic Chemistry