Continuous flow doebner–miller reaction and isolation using continuous stirred tank reactors

TitleContinuous flow doebner–miller reaction and isolation using continuous stirred tank reactors
Publication TypeJournal Article
Year of Publication2016
AuthorsYadav, MB, Kulkarni, S, Joshi, RA, Kulkarni, AA
JournalOrganic Process Research & Development
Volume20
Issue9
Pagination1621–1625
Date PublishedAUG
Abstract

Continuous flow Doebner–Miller synthesis of different quinaldines from respective anilines is demonstrated using sulfuric acid as a homogeneous catalyst. The extent of reaction was monitored for various parameters, namely, temperature, residence time, mole ratio of sulfuric acid to substrate, mole ratio of crotonaldehyde to substrate, and so forth. Continuous stirred reactors in series were used as a preferred configuration for this rection that generates byproduct in the form of sticky solid material. The approach has been extended for six different anilines, and the results are compared with batch reactions. Continuous stirred reactors in series with distributed dosing of crotonaldehyde facilitated a continuous flow reaction with lower byproduct formation, increased yields, and continuous workup and is a scalable approach.

DOI10.1021/acs.oprd.6b00179
Funding Agency

Council of Scientific & Industrial Research (CSIR) - India

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.922

Divison category: 
Chemical Engineering & Process Development
Organic Chemistry