Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers

TitleConformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers
Publication TypeJournal Article
Year of Publication2011
AuthorsRamesh, VVE, Roy, A, Vijayadas, KN, Kendhale, AM, Prabhakaran, P, Gonnade, RG, Puranik, VG, Sanjayan, GJ
JournalOrganic & Biomolecular Chemistry
Volume9
Issue2
Pagination367-369
Date PublishedNOV
ISSN1477-0520
Abstract

This communication describes the development of conformationally constrained unnatural aromatic amino acids, constructed on rigid backbone wherein the carboxyl and amino groups project in two dimensions (planes) on the aromatic framework. Such a feature offers the possibility of design and development of conformationally ordered synthetic oligomers with intriguing structural architectures distinct from those classically observed. Furthermore, such amino acids will have the potential to extend the conformational space available for foldamer design with diverse backbone conformation and structural architectures.

DOI10.1039/c0ob00593b
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.696

Divison category: 
Center for Material Characterization (CMC)
Organic Chemistry