Conformational studies of Ant-Pro motif-incorporated cyclic peptides: gramicidin S and avellanin

TitleConformational studies of Ant-Pro motif-incorporated cyclic peptides: gramicidin S and avellanin
Publication TypeJournal Article
Year of Publication2018
AuthorsKotmale, AS, Sangtani, E, Gonnade, RG, Sarkar, D, Burade, S, Rajamohanan, PR, Sanjayan, GJ
JournalNew Journal of Chemistry
Volume42
Issue2
Pagination1197-1201
Date PublishedJAN
Abstract

This paper reports conformational changes observed in cyclic bioactive peptides such as gramicidin S and avellanin upon incorporation of a pseudo-beta (C9) Ant-(D)Pro turn motif in their structural frameworks. Solution-state studies suggested that a synthetic gramicidin S analog exhibits a beta-sheet conformation with C9 and C17 intramolecular hydrogen bonding patterns, while its truncated analog disturbs the beta-sheet conformation. Structural details were obtained using a combination of CD studies, X-ray crystal structure studies and nOe-based MD simulation studies.

DOI10.1039/c7nj03701e
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.269

Divison category: 
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry