Comparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO)

TitleComparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO)
Publication TypeJournal Article
Year of Publication2012
AuthorsKotikam, V, Fernandes, M, Kumar, VAnil
JournalPhysical Chemistry Chemical Physics
Volume14
Issue43
Pagination15003-15006
Date PublishedSEP
Type of ArticleArticle
ISSN1463-9076
Abstract

The fluorescently labelled short octameric oligothymine sequences of DNA, PNA and PCNA were used in fluorescence quenching studies in conjunction with dispersed graphene oxide. The measurable restoration of their fluorescence by complementary oligodeoxyadenylate was compared. This is the first study aimed at replacing the natural DNA probes with synthetic DNA mimics that show excellent properties in terms of formation of very strong duplexes with cDNA in addition to their stability towards proteases and nucleases.

DOI10.1039/c2cp42770b
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.829

Divison category: 
Organic Chemistry