``Clickable'' SBA-15 mesoporous materials: synthesis, characterization and their reaction with alkynes

Title``Clickable'' SBA-15 mesoporous materials: synthesis, characterization and their reaction with alkynes
Publication TypeJournal Article
Year of Publication2009
AuthorsMalvi, B, Sarkar, BR, Pati, D, Mathew, R, Ajithkumar, TG, Gupta, SSen
JournalJournal of Materials Chemistry
Volume19
Issue10
Pagination1409-1416
Date PublishedJAN
Type of ArticleArticle
ISSN0959-9428
Abstract

SBA-15 mesoporous silica has been functionalized with azidopropyl groups through both one-pot co-condensation and post-synthetic grafting. For both these methodologies, azidopropyltriethoxysilane was used to introduce the azidopropyl groups. The azidopropyl modified SBA-15 material synthesized by one-pot co-condensation had hexagonal crystallographic order, pore diameters up of 50 angstrom, and the content of azidopropyl groups was found to be 1.3 mmol g(-1). The presence of the azidopropyl group was confirmed by multinuclear ((13)C, (29)Si) solid state NMR and IR spectroscopy. Both these materials underwent very efficient Cu(I)-catalyzed azide alkyne ``click'' reaction (CuAAC) with a variety of alkynes. Nearly 85% of the azide present in the SBA-15 material was converted to the corresponding triazole when propargyl alcohol was used as the substrate. This methodology was also used to incorporate mannose into SBA-15. Incubation of this mannose labeled SBA-15 with fluorescein labeled Concanavalin-A led to the formation of a fluorescent silica-protein hybrid material. The ease of synthesis for the azide labeled SBA-15 material together with its ability to undergo very efficient chemoselective CuAAC in water would make it a very attractive platform for the development of covalently anchored catalysts, enzymes and sensors.

DOI10.1039/b815350g
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

5.099

Divison category: 
Central NMR Facility
Chemical Engineering & Process Development