Carbonylations and hydroformylations for fine chemicals

TitleCarbonylations and hydroformylations for fine chemicals
Publication TypeBook Chapter
Year of Publication2016
AuthorsKelkar, AA
Book TitleIndustrial catalytic processes for fine and specialty chemicals
Pagination 663-692
PublisherElsevier Inc.
Abstract

Carbonylation reactions (hydroformylation and carbonylation) constitute one of the most powerful tools for C. C bond formation in organic synthesis and represent an outstanding example of the application of homogeneous catalysis on an industrial scale. Carbonylation reactions have the potential to provide clean, atom-efficient routes for the synthesis of molecules with carboxylic acid, aldehyde and amide functional groups. However, catalyst product separation is a major problem for the application of homogeneous catalysts on an industrial scale. The manufacture of ibuprofen, one of the important antiinflammatory drugs involving palladium-catalyzed carbonylation, was the path-breaking technology in pharmaceutical chemistry. A significant amount of work is being carried out on the development of selective catalysts for specialty chemical synthesis. This chapter presents recent advances in the development of new catalysts for carbonylation reactions. Various strategies developed for the heterogenization of catalysts are also presented, with an emphasis on specialty chemicals.

DOI10.1016/B978-0-12-801457-8.00014-8
Type of Journal (Indian or Foreign)

Foreign

Divison category: 
Chemical Engineering & Process Development