Calcium phosphate nanocapsule crowned multiwalled carbon nanotubes for pH triggered intracellular anticancer drug release

TitleCalcium phosphate nanocapsule crowned multiwalled carbon nanotubes for pH triggered intracellular anticancer drug release
Publication TypeJournal Article
Year of Publication2015
AuthorsBanerjee, SS, Todkar, KJ, Khutale, GV, Chate, GP, Biradar, AV, Gawande, MB, Zboril, R, Khandare, JJ
JournalJournal of Materials Chemistry B
Volume3
Issue19
Pagination3931-3939
Date PublishedAPR
ISSN2050-750X
Abstract

We report calcium phosphate (CaP) nanocapsule crowned multi-walled carbon nanotubes (CNT-GSH-G4-CaP) as a novel platform for intracellular delivery of an anticancer drug. As a proof-of-concept, CNT-GSH-G4-CaP demonstrates release of anticancer drug doxorubicin hydrochloride (DOX) within intracellular lysosomes from the interior cavity of CNT upon pH triggered CaP dissolution. Importantly, we found that the CNT with a CaP nanolid can efficiently prevent untimely drug release at physiological pH but promotes DOX release at increased acidic milieu as observed in subcellular compartments such as lysosomes (similar to 5.0). This ``zero premature release'' characteristic is of clinical significance in delivering cytotoxic drugs, by reducing systemic toxicity and thus beneficial for the effective anticancer treatment. We envision that this pH triggered CaP crowned CNT nanosystem would lead to a new generation of self-regulated platforms for intracellular delivery of a variety of anticancer drugs.

DOI10.1039/c5tb00534e
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

4.872

Divison category: 
Catalysis and Inorganic Chemistry