Biomimetic synthesis of CdSe nanoparticles with potential bioimaging applications

TitleBiomimetic synthesis of CdSe nanoparticles with potential bioimaging applications
Publication TypeJournal Article
Year of Publication2017
AuthorsAnsary, AAyoobul, Uddin, I, Khan, MI
JournalInternational Journal of Pharmaceutical Sciences and Research
Issue22
Pagination2526-2532
Date PublishedJUN
Type of ArticleArticle
Abstract

This study presents in vitro biomimetic synthesis of CdSe nanoparticles using the enzyme, NADPH dependent-Nitrate reductase purified from fungus, Fusarium oxysporum. The synthesis of CdSe nanoparticles was accomplished in the presence of a synthetic peptide having amino acid sequence (γ-Glu-Cys-Glu-Cys)-Gly, which acted as binding molecule. The nanoparticles were synthesized in the size range of 3.9–9.0 nm was analysed using TEM. Further characterization of nanoparticles was done using techniques such as UV, PL, XPS, and FTIR. The as-synthesized CdSe nanoparticles were water dispersible containing free reactive amino groups. These CdSe nanoparticles were conjugated with bi-antennary and tri-antennary glycopeptides opening up the possibilities for their applications in bioimaging. These significant observations will help better understand the mechanism of biosynthesis of fluorescent nanoparticles using fungi. These findings promise an alternative strategy for an eco-friendly, economical, and large-scale synthesis of water dispersible CdSe nanoparticles. These CdSe nanoparticles have promising biomedical-imaging applications without a need for further functionalization.

DOI10.13040/IJPSR.0975-8232.8(6).2526-32
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.11

Divison category: 
Biochemical Sciences