Biocatalyst mediated functionalization of salannin, an insecticidal limonoid

TitleBiocatalyst mediated functionalization of salannin, an insecticidal limonoid
Publication TypeJournal Article
Year of Publication2014
AuthorsHaldar, S, Kolet, SP, Dandekar, DS, Kale, BS, Gonnade, RG, Thulasiram, HV
JournalRSC Advances
Volume4
Issue53
Pagination27661-27664
Date PublishedJUN
Type of ArticleArticle
ISSN2046-2069
Abstract

Transformation of salannin, an insecticidal C-seco limonoid was investigated using a fungal system, Cunninghamella echinulata. Salannin was efficiently converted into two metabolites, where the C-17 furan moiety was transformed into gamma-hydroxybutenolide (salanninolide) and N-(2-hydroxyethyl)-alpha,beta-unsaturated-gamma-lactam (salanninactam) analogues. Present studies have indicated salanninolide to be a metabolite in the C-seco limonoid biosynthetic pathway.

DOI10.1039/c4ra04652h
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.289

Divison category: 
Organic Chemistry