Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study

TitleAsymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study
Publication TypeJournal Article
Year of Publication2014
AuthorsShende, VS, Shingote, SK, Deshpande, SH, Kuriakose, N, Vanka, K, Kelkar, AA
JournalRSC Advances
Volume4
Issue86
Pagination46351-46356
Date PublishedSEP
Type of ArticleArticle
ISSN2046-2069
Abstract

Asymmetric transfer hydrogenation of various cyclic imines proceeded efficiently with water/methanol co-solvent media in 20 min with excellent yields and enantioselectivities by employing Rh-TsDPEN catalyst and sodium formate as a hydrogen donor. The role of the co-solvent in enhanced productivity of the reaction was investigated by DFT. The mechanism for ATH of the imines has been discussed on the basis of the DFT study.

DOI10.1039/c4ra07964g
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.289

Divison category: 
Chemical Engineering & Process Development