Asymmetric total synthesis of eicosanoid

TitleAsymmetric total synthesis of eicosanoid
Publication TypeJournal Article
Year of Publication2005
AuthorsMohapatra, DK, Yellol, GS
JournalArkivoc
IssuePart 3
Pagination144-155
Date PublishedJAN
Type of ArticleArticle
Keywordscyclopropanation, eicosanoid, lipoxygenase inhibitors, Ring-closing metathesis, Stereoselective
Abstract

An asymmetric total synthesis of eicosanoid 4 starting from 2,2- dimethyl-( R)- 1,3- dioxolane-4- carbaldehyde is described. The key steps involved for the synthesis include modified Simmons-Smith cyclopropanation, stereoselective reduction, ring-closing metathesis (RCM) and Nozaki- Hiyama- Kishi coupling reaction.

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.177

Divison category: 
Organic Chemistry